Development and Validation of a Scalable Next-Generation Sequencing System for Assessing Relevant Somatic Variants in Solid Tumors12
نویسندگان
چکیده
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors Daniel H. Hovelson, Andrew S. McDaniel, Andi K. Cani, Bryan Johnson, Kate Rhodes, Paul D. Williams, Santhoshi Bandla, Geoffrey Bien, Paul Choppa, Fiona Hyland, Rajesh Gottimukkala, Guoying Liu, Manimozhi Manivannan, Jeoffrey Schageman, Efren Ballesteros-Villagrana, Catherine S. Grasso, Michael J. Quist, Venkata Yadati, Anmol Amin, Javed Siddiqui, Bryan L. Betz, Karen E. Knudsen, Kathleen A. Cooney, Felix Y. Feng, Michael H. Roh, Peter S. Nelson, Chia-Jen Liu, David G. Beer, Peter Wyngaard, Arul M. Chinnaiyan, Seth Sadis, Daniel R. Rhodes, Scott A. Tomlins SUPPLEMENTARY MATERIALS Supplementary Materials and Methods Pages 1-7 Supplementary References Page 8 Supplementary Figure Legends Pages 9-12 Supplementary Figures 1-8 Pages 13-20 Supplementary Tables Pages 21-82
منابع مشابه
Development and validation of a scalable next-generation sequencing system for assessing relevant somatic variants in solid tumors.
Next-generation sequencing (NGS) has enabled genome-wide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required to identify and prioritize actionable variants. Such approaches are not scalable, preventing widespread adoption. Likewise, most targeted NGS approaches fail to assess key relevant genomic alteration classes. To address these ch...
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عنوان ژورنال:
دوره 17 شماره
صفحات -
تاریخ انتشار 2015